2010-04-22 First version, including 15.2 personal genomes. Kaviar lists 12,310,021 variant sites.
2010-05-25 Second version, including dbSNP 130, pilot 1 of 1000Genomes, 15.2 personal genomes, Saqqaq genome. First version of Kaviar.pm module.
2010-06-15 Third version, including the three pilots of the 1000Genomes project and the Neanderthal genome. Improvements to web interface. Kaviar lists ~26.5 million variant sites.
2010-07-30 Updated to dbSNP version 131. Kaviar lists 29,393,542 variant sites.
2010-09-21 Updated data from PGP. Kaviar lists 29,485,279 variant sites.
2010-10-04 Internal restructuring for efficient querying.
2011-05-06 Updated dbSNP to version 132, included Complete Genomics' 69 genomes. Kaviar now supports genome freezes hg18 (35,325,832 variant sites) and hg19 (35,422,369 variant sites).
2011-05-10 Internal restructuring to fully binary format.
2011-05-13 Added the phase1 release of the 1000Genomes project. Kaviar now lists 56,043,986 hg18 variant sites, and 56,193,924 hg19 variant sites.
2011-05-18 Added variants observed in at least three of 44 genomes sequenced by the Institute for Systems Biology. Also added the 200 exome data from Denmark. Kaviar now lists 56,074,711 hg18 variant sites and 56,224,468 hg19 variant sites.
2011-06-02 Added variants observed in RNA-seq data sets (Illumina BodyMap 1.0, LiverSex project), as computed by Juan Caballero. Juan also re-computed SNVs based on data from the Neanderthal genome project, losing ~3 million probable false positives. Improved the annotation of projects, populations and citations. Kaviar now lists 53,205,796 hg18 variant sites and 53,356,040 hg19 variant sites.
2011-06-06 Implemented JSON output.
2011-06-07 Established http://db.systemsbiology.net/kaviar as URL for Kaviar's homepage. Thanks to Eric Deutsch for setting this up!
2011-06-15 Added anonymous Irishman genome. Kaviar now lists 53,320,759 hg18 variant sites and 53,470,996 hg19 variant sites.
2011-06-16 Many code enhancements, additional tools by Denise Mauldin for accessing the database.
2011-06-17 Added Greg Lucier's genome.
2011-06-20 Added variants observed in the Denisovan genome and in the seven modern humans sampled in that project.
2011-06-21 Fixed a bug that was excluding one complete genome, and removed some duplicate data. Kaviar now lists 53,524,959 hg18 variant sites and 53,675,039 hg19 variant sites.
2011-06-23 Fixed a minor encoding bug, added 10 Korean genomes. Kaviar now lists 54,421,475 hg18 variant sites and 54,576,128 hg19 variant sites.
2011-07-11 Added the genomes of John West and David Ewing Duncan, and variants observed in RNA-seq data set: Illumina BodyMap 2.0, as computed by Juan Caballero. Kaviar now lists 54,902,634 hg18 variant sites and 55,058,104 hg19 variant sites.
2011-07-13 Improved web interface. When no variants are known for a query site, the closest known variant is mentioned, and if it looks like the user is specifying the wrong coordinate system, this is hinted in the output.
2011-07-26 Removed the less-reliable Neanderthal and Denisovan variants. Modern humans sampled by those projects are still included.
2011-07-28 Implemented VCF output format. Improved documentation.
2011-08-02 Added Gordon Moore's genome.
2011-08-04 Created Google group Kaviar-announce: http://groups.google.com/d/forum/kaviar-announce
2011-09-20 Added to the web interface option to upload a file with coordinates. Redesigned web interface design for clarity.
2011-09-22 Kaviar paper accepted for publication in Bioinformatics.
2011-09-30 Kaviar paper published: http://www.ncbi.nlm.nih.gov/pubmed/21965822
2011-10-14 Belatedly released version 110823, including dbSNP version 134.
2011-11-21 Updated Kaviar to include dbSNP version 135.
2011-12-30 Improved MAF estimates.
2011-02-03 Added Manuel Corpas' variants.
2012-03-02 Completed reimplementation based on tabix, to support variants other than SNVs.
2012-03-14 Added ESP5400 data set from NHLBI Exome Sequencing Project (https://esp.gs.washington.edu/drupal/).
2012-04-19 Released first version of Kaviar2 through the web interface.
2012-04-25 Fixed a bug in which a few SNVs would liftOver across chromosomes and be recorded in the wrong orientation.
2015-01-14 141127 build released. Indels and complex variants incorporated. Many new data sources. RNAseq data removed. Download provided in VCF format.
2015-09-23 150810-Public build released. 3842 samples from Inova Translational Medicine Institute added. ADNI added. Update to dbSNP 144 and ExAC v3. Most variants normalized. More ranged variants included.
2015-09-24 Platform-specific variants annotated in table, text formats under "Comments"
2015-11-17 (web interface only) Remove double-counting of 1000Genomes variants within exome due to inclusion of 1000Genomes in ExAC (63000exomes). Fix bug re: platform-specfic annotations.
2015-12-26 Accept dbSNP rsids as input in web interface.
2016-01-07 Filter by MAF cutoff in web interface.
2016-01-08 Filter by variant type (SNVs or indels/substitutions) in web interface.
2016-01-16 160113-Public build released. Various small issues addressed. MSBB and iJGVD data added. ADNI data removed.
2016-02-02 Fixed bug by which hg19 exome boundaries were being used for hg18 and hg38, leading to incorrect AN & AF values.
2016-02-29 160204-Public build released. UK10K duplicates removed. Removed exome boundary bug from VCF files. Support for hg18 discontinued.
2016-03-08 Report when a variant is absent from specified reference genome but present in the other (web interface, table output format only).
2016-03-08 When MAF or Variant type filters are on, don't print anything for positions where no variant passes filters (web interface).
2016-03-22 Filter by platform-specificity in web interface.
2016-04-08 Bug fixes: report MAF=1 and MAF=0; corrected mistake in reporting closest variant when no results.